Development of an Automated MRI-Based Diagnostic Protocol for Amyotrophic Lateral Sclerosis Using Disease-Specific Pathognomonic Features: A Quantitative Disease-State Classification Study.

Despite significant advances in quantitative neuroimaging, the diagnosis of ALS remains clinical and MRI-based biomarkers are not currently used to aid the diagnosis.The objective of this study jetstream ice therapy parts is to develop a robust, disease-specific, multimodal classification protocol and validate its diagnostic accuracy in independent

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Effect of biological sex and short-term high-fat diet on cellular proliferation, ribosomal biogenesis, and targeted protein abundance in murine articular cartilage

Objective: To identify factors contributing to sex-differences in OA risk by evaluating the short-term effect of high-fat (HF) diet on sex-specific changes in cartilage cell proliferation, ribosomal biogenesis, and targeted extra-cellular and cellular protein abundance.Materials and methods: Knee cartilage was harvested to the subchondral bone from

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Percutaneous Coronary Intervention via Distal Transradial Approach: Strengths, Weaknesses, Opportunities and Challenges

As a new approach for percutaneous coronary intervention, distal transradial approach (dTRA) is increasingly applied in clinical practice.Thus dTRA is superior to transradial artery approach in improving patient and surgeon comfort, reducing the incidence of complications and forearm arterial injuries, while it also has many limitations, such as lo

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